Serine protease HTRA2, mitochondrial (HTRA2)

About Serine protease HTRA2, mitochondrial

Serine protease HTRA2, mitochondrial (HTRA2) is a protein from Homo sapiens identified by UniProt accession O43464, 458 residues long. MolForge cross-references it against 0 known binders and 356 disease associations.

Target properties

Protein name	Serine protease HTRA2, mitochondrial
UniProt accession	O43464
Gene	HTRA2
Organism	Homo sapiens
Length	458 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (356)

Diseases linked to this target (Open Targets).

3-methylglutaconic aciduria type 8 · score 0.80
3-methylglutaconic aciduria · score 0.50
Young adult-onset Parkinsonism · score 0.49
neutropenia · score 0.46
genetic disorder · score 0.19
Leigh syndrome · score 0.15
breast ductal adenocarcinoma · score 0.11
hepatocellular carcinoma · score 0.10
rheumatoid arthritis · score 0.09
Rheumatoid arthritis · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43464-F1	alphafold	PREDICTED	74.45	—

Amino-acid sequence (458 residues)

MAAPRAGRGA GWSLRAWRAL GGIRWGRRPR LTPDLRALLT SGTSDPRARV TYGTPSLWAR LSVGVTEPRA CLTSGTPGPR AQLTAVTPDT RTREASENSG TRSRAWLAVA LGAGGAVLLL LWGGGRGPPA VLAAVPSPPP ASPRSQYNFI ADVVEKTAPA VVYIEILDRH PFLGREVPIS NGSGFVVAAD GLIVTNAHVV ADRRRVRVRL LSGDTYEAVV TAVDPVADIA TLRIQTKEPL PTLPLGRSAD VRQGEFVVAM GSPFALQNTI TSGIVSSAQR PARDLGLPQT NVEYIQTDAA IDFGNSGGPL VNLDGEVIGV NTMKVTAGIS FAIPSDRLRE FLHRGEKKNS SSGISGSQRR YIGVMMLTLS PSILAELQLR EPSFPDVQHG VLIHKVILGS PAHRAGLRPG DVILAIGEQM VQNAEDVYEA VRTQSQLAVQ IRRGRETLTL YVTPEVTE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards