Krueppel-like factor 4 (KLF4)

About Krueppel-like factor 4

Krueppel-like factor 4 (KLF4) is a protein from Homo sapiens identified by UniProt accession O43474, 513 residues long. MolForge cross-references it against 0 known binders and 672 disease associations.

Target properties

Protein name	Krueppel-like factor 4
UniProt accession	O43474
Gene	KLF4
Organism	Homo sapiens
Length	513 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (672)

Diseases linked to this target (Open Targets).

breast carcinoma · score 0.50
neurodegenerative disease · score 0.48
prostate carcinoma · score 0.39
Secretory Meningioma · score 0.37
Chordoid Meningioma · score 0.37
Meningothelial Meningioma · score 0.37
Transitional Meningioma · score 0.37
Atypical Meningioma · score 0.37
Endometrial Endometrioid Adenocarcinoma · score 0.37
meningioma · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43474-F1	alphafold	PREDICTED	48.94	—

Amino-acid sequence (513 residues)

MRQPPGESDM AVSDALLPSF STFASGPAGR EKTLRQAGAP NNRWREELSH MKRLPPVLPG RPYDLAAATV ATDLESGGAG AACGGSNLAP LPRRETEEFN DLLDLDFILS NSLTHPPESV AATVSSSASA SSSSSPSSSG PASAPSTCSF TYPIRAGNDP GVAPGGTGGG LLYGRESAPP PTAPFNLADI NDVSPSGGFV AELLRPELDP VYIPPQQPQP PGGGLMGKFV LKASLSAPGS EYGSPSVISV SKGSPDGSHP VVVAPYNGGP PRTCPKIKQE AVSSCTHLGA GPPLSNGHRP AAHDFPLGRQ LPSRTTPTLG LEEVLSSRDC HPALPLPPGF HPHPGPNYPS FLPDQMQPQV PPLHYQGQSR GFVARAGEPC VCWPHFGTHG MMLTPPSSPL ELMPPGSCMP EEPKPKRGRR SWPRKRTATH TCDYAGCGKT YTKSSHLKAH LRTHTGEKPY HCDWDGCGWK FARSDELTRH YRKHTGHRPF QCQKCDRAFS RSDHLALHMK RHF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards