Aflatoxin B1 aldehyde reductase member 2 (AKR7A2)

About Aflatoxin B1 aldehyde reductase member 2

Aflatoxin B1 aldehyde reductase member 2 (AKR7A2) is a protein from Homo sapiens identified by UniProt accession O43488, 359 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	Aflatoxin B1 aldehyde reductase member 2
UniProt accession	O43488
Gene	AKR7A2
Organism	Homo sapiens
Length	359 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.52
lysosomal storage disease · score 0.37
urinary metabolite measurement · score 0.30
viral load · score 0.26
blood protein measurement · score 0.25
Thyroid preparation use measurement · score 0.15
hypothyroidism · score 0.11
heel bone mineral density · score 0.08
refractive error measurement · score 0.08
appendicular lean mass · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43488-F1	alphafold	PREDICTED	93.06	—

Amino-acid sequence (359 residues)

MLSAASRVVS RAAVHCALRS PPPEARALAM SRPPPPRVAS VLGTMEMGRR MDAPASAAAV RAFLERGHTE LDTAFMYSDG QSETILGGLG LGLGGGDCRV KIATKANPWD GKSLKPDSVR SQLETSLKRL QCPQVDLFYL HAPDHGTPVE ETLHACQRLH QEGKFVELGL SNYASWEVAE ICTLCKSNGW ILPTVYQGMY NATTRQVETE LFPCLRHFGL RFYAYNPLAG GLLTGKYKYE DKDGKQPVGR FFGNSWAETY RNRFWKEHHF EAIALVEKAL QAAYGASAPS VTSAALRWMY HHSQLQGAHG DAVILGMSSL EQLEQNLAAT EEGPLEPAVV DAFNQAWHLV AHECPNYFR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards