DNA repair protein RAD51 homolog 3 (RAD51C)

About DNA repair protein RAD51 homolog 3

DNA repair protein RAD51 homolog 3 (RAD51C) is a protein from Homo sapiens identified by UniProt accession O43502, 376 residues long. MolForge cross-references it against 0 known binders and 281 disease associations.

Target properties

Protein name	DNA repair protein RAD51 homolog 3
UniProt accession	O43502
Gene	RAD51C
Organism	Homo sapiens
Length	376 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (281)

Diseases linked to this target (Open Targets).

Hereditary breast and ovarian cancer syndrome · score 0.75
Fanconi anemia · score 0.70
ovarian cancer · score 0.65
hereditary neoplastic syndrome · score 0.58
Inherited cancer-predisposing syndrome · score 0.58
hereditary breast ovarian cancer syndrome · score 0.56
cancer · score 0.55
ovarian neoplasm · score 0.52
gastric cancer · score 0.52
breast cancer · score 0.50

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43502-F1	alphafold	PREDICTED	84.36	—

Amino-acid sequence (376 residues)

MRGKTFRFEM QRDLVSFPLS PAVRVKLVSA GFQTAEELLE VKPSELSKEV GISKAEALET LQIIRRECLT NKPRYAGTSE SHKKCTALEL LEQEHTQGFI ITFCSALDDI LGGGVPLMKT TEICGAPGVG KTQLCMQLAV DVQIPECFGG VAGEAVFIDT EGSFMVDRVV DLATACIQHL QLIAEKHKGE EHRKALEDFT LDNILSHIYY FRCRDYTELL AQVYLLPDFL SEHSKVRLVI VDGIAFPFRH DLDDLSLRTR LLNGLAQQMI SLANNHRLAV ILTNQMTTKI DRNQALLVPA LGESWGHAAT IRLIFHWDRK QRLATLYKSP SQKECTVLFQ IKPQGFRDTV VTSACSLQTE GSLSTRKRSR DPEEEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards