About Beta-1,4-glucuronyltransferase 1
Beta-1,4-glucuronyltransferase 1 (B4GAT1) is a protein
from Homo sapiens identified by UniProt accession
O43505, 415 residues long.
MolForge cross-references it against 0 known binders and
62 disease associations.
Target properties
| Protein name | Beta-1,4-glucuronyltransferase 1 |
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| UniProt accession | O43505 |
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| Gene | B4GAT1 |
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| Organism | Homo sapiens |
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| Length | 415 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (62)
Diseases linked to this target (Open Targets).
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A13 · score 0.77
- muscular dystrophy-dystroglycanopathy, type A · score 0.60
- congenital muscular dystrophy · score 0.37
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A1 · score 0.26
- genetic disorder · score 0.18
- self reported educational attainment · score 0.10
- attention deficit hyperactivity disorder · score 0.09
- schizophrenia 15 · score 0.07
- attention deficit-hyperactivity disorder 8 · score 0.07
- handedness · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43505-F1 | alphafold | PREDICTED | 88.45 | — |
Amino-acid sequence (415 residues)
MQMSYAIRCA FYQLLLAALM LVAMLQLLYL SLLSGLHGQE EQDQYFEFFP PSPRSVDQVK AQLRTALASG GVLDASGDYR VYRGLLKTTM DPNDVILATH ASVDNLLHLS GLLERWEGPL SVSVFAATKE EAQLATVLAY ALSSHCPDMR ARVAMHLVCP SRYEAAVPDP REPGEFALLR SCQEVFDKLA RVAQPGINYA LGTNVSYPNN LLRNLAREGA NYALVIDVDM VPSEGLWRGL REMLDQSNQW GGTALVVPAF EIRRARRMPM NKNELVQLYQ VGEVRPFYYG LCTPCQAPTN YSRWVNLPEE SLLRPAYVVP WQDPWEPFYV AGGKVPTFDE RFRQYGFNRI SQACELHVAG FDFEVLNEGF LVHKGFKEAL KFHPQKEAEN QHNKILYRQF KQELKAKYPN SPRRC
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