About Mediator of RNA polymerase II transcription subunit 7
Mediator of RNA polymerase II transcription subunit 7 (MED7) is a protein
from Homo sapiens identified by UniProt accession
O43513, 233 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Mediator of RNA polymerase II transcription subunit 7 |
|---|
| UniProt accession | O43513 |
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| Gene | MED7 |
|---|
| Organism | Homo sapiens |
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| Length | 233 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (22)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- breast adenocarcinoma · score 0.11
- Thyroid preparation use measurement · score 0.08
- breast cancer · score 0.05
- thyroid disease · score 0.04
- hepatocellular carcinoma · score 0.04
- neoplasm · score 0.03
- heel bone mineral density · score 0.03
- T-cell immunoglobulin and mucin domain 1 measurement · score 0.02
- respiratory system disease · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43513-F1 | alphafold | PREDICTED | 79.24 | — |
Amino-acid sequence (233 residues)
MGEPQQVSAL PPPPMQYIKE YTDENIQEGL APKPPPPIKD SYMMFGNQFQ CDDLIIRPLE SQGIERLHPM QFDHKKELRK LNMSILINFL DLLDILIRSP GSIKREEKLE DLKLLFVHVH HLINEYRPHQ ARETLRVMME VQKRQRLETA ERFQKHLERV IEMIQNCLAS LPDDLPHSEA GMRVKTEPMD ADDSNNCTGQ NEHQRENSGH RRDQIIEKDA ALCVLIDEMN ERP
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