About WAS/WASL-interacting protein family member 1
WAS/WASL-interacting protein family member 1 (WIPF1) is a protein
from Homo sapiens identified by UniProt accession
O43516, 503 residues long.
MolForge cross-references it against 0 known binders and
355 disease associations.
Target properties
| Protein name | WAS/WASL-interacting protein family member 1 |
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| UniProt accession | O43516 |
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| Gene | WIPF1 |
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| Organism | Homo sapiens |
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| Length | 503 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (355)
Diseases linked to this target (Open Targets).
- Wiskott-Aldrich syndrome · score 0.63
- mean platelet volume · score 0.48
- platelet component distribution width · score 0.43
- atrial fibrillation · score 0.42
- systolic blood pressure · score 0.36
- pulse pressure measurement · score 0.36
- Agents acting on the renin-angiotensin system use measurement · score 0.29
- atrial flutter · score 0.28
- QRS amplitude · score 0.27
- QRS complex · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43516-F1 | alphafold | PREDICTED | 58.50 | — |
Amino-acid sequence (503 residues)
MPVPPPPAPP PPPTFALANT EKPTLNKTEQ AGRNALLSDI SKGKKLKKTV TNDRSAPILD KPKGAGAGGG GGGFGGGGGF GGGGGGGGGG SFGGGGPPGL GGLFQAGMPK LRSTANRDND SGGSRPPLLP PGGRSTSAKP FSPPSGPGRF PVPSPGHRSG PPEPQRNRMP PPRPDVGSKP DSIPPPVPST PRPIQSSPHN RGSPPVPGGP RQPSPGPTPP PFPGNRGTAL GGGSIRQSPL SSSSPFSNRP PLPPTPSRAL DDKPPPPPPP VGNRPSIHRE AVPPPPPQNN KPPVPSTPRP SASSQAPPPP PPPSRPGPPP LPPSSSGNDE TPRLPQRNLS LSSSTPPLPS PGRSGPLPPP PSERPPPPVR DPPGRSGPLP PPPPVSRNGS TSRALPATPQ LPSRSGVDSP RSGPRPPLPP DRPSAGAPPP PPPSTSIRNG FQDSPCEDEW ESRFYFHPIS DLPPPEPYVQ TTKSYPSKLA RNESRSGSNR RERGAPPLPP IPR
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