About Bcl-2-like protein 11
Bcl-2-like protein 11 (BCL2L11) is a protein
from Homo sapiens identified by UniProt accession
O43521, 198 residues long.
MolForge cross-references it against 0 known binders and
736 disease associations.
Target properties
| Protein name | Bcl-2-like protein 11 |
|---|
| UniProt accession | O43521 |
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| Gene | BCL2L11 |
|---|
| Organism | Homo sapiens |
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| Length | 198 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (736)
Diseases linked to this target (Open Targets).
- cancer · score 0.55
- neurodegenerative disease · score 0.51
- mean corpuscular volume · score 0.49
- monocyte count · score 0.47
- prostate carcinoma · score 0.47
- mean corpuscular hemoglobin concentration · score 0.47
- reticulocyte count · score 0.47
- monocyte percentage of leukocytes · score 0.46
- erythrocyte count · score 0.45
- heel bone mineral density · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43521-F1 | alphafold | PREDICTED | 60.06 | — |
Amino-acid sequence (198 residues)
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR MVILRLLRYI VRLVWRMH
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