DNA repair protein XRCC3 (XRCC3)

About DNA repair protein XRCC3

DNA repair protein XRCC3 (XRCC3) is a protein from Homo sapiens identified by UniProt accession O43542, 346 residues long. MolForge cross-references it against 0 known binders and 236 disease associations.

Target properties

Protein name	DNA repair protein XRCC3
UniProt accession	O43542
Gene	XRCC3
Organism	Homo sapiens
Length	346 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (236)

Diseases linked to this target (Open Targets).

hereditary breast carcinoma · score 0.40
breast carcinoma · score 0.37
Hereditary breast cancer · score 0.37
breast neoplasm · score 0.37
ovarian cancer · score 0.21
cutaneous melanoma · score 0.19
familial melanoma · score 0.18
susceptibility to breast cancer · score 0.18
sex hormone-binding globulin measurement · score 0.17
vitamin D measurement · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43542-F1	alphafold	PREDICTED	87.30	—

Amino-acid sequence (346 residues)

MDLDLLDLNP RIIAAIKKAK LKSVKEVLHF SGPDLKRLTN LSSPEVWHLL RTASLHLRGS SILTALQLHQ QKERFPTQHQ RLSLGCPVLD ALLRGGLPLD GITELAGRSS AGKTQLALQL CLAVQFPRQH GGLEAGAVYI CTEDAFPHKR LQQLMAQQPR LRTDVPGELL QKLRFGSQIF IEHVADVDTL LECVNKKVPV LLSRGMARLV VIDSVAAPFR CEFDSQASAP RARHLQSLGA TLRELSSAFQ SPVLCINQVT EAMEEQGAAH GPLGFWDERV SPALGITWAN QLLVRLLADR LREEEAALGC PARTLRVLSA PHLPPSSCSY TISAEGVRGT PGTQSH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards