About DNA repair protein XRCC2
DNA repair protein XRCC2 (XRCC2) is a protein
from Homo sapiens identified by UniProt accession
O43543, 280 residues long.
MolForge cross-references it against 0 known binders and
124 disease associations.
Target properties
| Protein name | DNA repair protein XRCC2 |
|---|
| UniProt accession | O43543 |
|---|
| Gene | XRCC2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 280 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (124)
Diseases linked to this target (Open Targets).
- spermatogenic failures 50 · score 0.59
- Fanconi anemia · score 0.56
- cancer · score 0.55
- Inherited cancer-predisposing syndrome · score 0.55
- hereditary neoplastic syndrome · score 0.55
- mean platelet volume · score 0.50
- Fanconi anemia complementation group U · score 0.48
- myelodysplastic syndrome · score 0.46
- acute myeloid leukemia · score 0.46
- platelet count · score 0.44
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43543-F1 | alphafold | PREDICTED | 87.11 | — |
Amino-acid sequence (280 residues)
MCSAFHRAES GTELLARLEG RSSLKEIEPN LFADEDSPVH GDILEFHGPE GTGKTEMLYH LTARCILPKS EGGLEVEVLF IDTDYHFDML RLVTILEHRL SQSSEEIIKY CLGRFFLVYC SSSTHLLLTL YSLESMFCSH PSLCLLILDS LSAFYWIDRV NGGESVNLQE STLRKCSQCL EKLVNDYRLV LFATTQTIMQ KASSSSEEPS HASRRLCDVD IDYRPYLCKA WQQLVKHRMF FSKQDDSQSS NQFSLVSRCL KSNSLKKHFF IIGESGVEFC
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