About Protein-glutamine gamma-glutamyltransferase 5
Protein-glutamine gamma-glutamyltransferase 5 (TGM5) is a protein
from Homo sapiens identified by UniProt accession
O43548, 720 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Protein-glutamine gamma-glutamyltransferase 5 |
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| UniProt accession | O43548 |
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| Gene | TGM5 |
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| Organism | Homo sapiens |
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| Length | 720 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (47)
Diseases linked to this target (Open Targets).
- acral peeling skin syndrome · score 0.76
- genetic disorder · score 0.47
- peeling skin syndrome 1 · score 0.42
- glioblastoma multiforme · score 0.23
- self reported educational attainment · score 0.23
- breast adenocarcinoma · score 0.22
- PHF-tau measurement · score 0.22
- mathematical ability · score 0.20
- head and neck squamous cell carcinoma · score 0.18
- clear cell renal carcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43548-F1 | alphafold | PREDICTED | 91.53 | — |
Amino-acid sequence (720 residues)
MAQGLEVALT DLQSSRNNVR HHTEEITVDH LLVRRGQAFN LTLYFRNRSF QPGLDNIIFV VETGPLPDLA LGTRAVFSLA RHHSPSPWIA WLETNGATST EVSLCAPPTA AVGRYLLKIH IDSFQGSVTA YQLGEFILLF NPWCPEDAVY LDSEPQRQEY VMNDYGFIYQ GSKNWIRPCP WNYGQFEDKI IDICLKLLDK SLHFQTDPAT DCALRGSPVY VSRVVCAMIN SNDDNGVLNG NWSENYTDGA NPAEWTGSVA ILKQWNATGC QPVRYGQCWV FAAVMCTVMR CLGIPTRVIT NFDSGHDTDG NLIIDEYYDN TGRILGNKKK DTIWNFHVWN ECWMARKDLP PAYGGWQVLD ATPQEMSNGV YCCGPASVRA IKEGEVDLNY DTPFVFSMVN ADCMSWLVQG GKEQKLHQDT SSVGNFISTK SIQSDERDDI TENYKYEEGS LQERQVFLKA LQKLKARSFH GSQRGAELQP SRPTSLSQDS PRSLHTPSLR PSDVVQVSLK FKLLDPPNMG QDICFVLLAL NMSSQFKDLK VNLSAQSLLH DGSPLSPFWQ DTAFITLSPK EAKTYPCKIS YSQYSQYLST DKLIRISALG EEKSSPEKIL VNKIITLSYP SITINVLGAA VVNQPLSIQV IFSNPLSEQV EDCVLTVEGS GLFKKQQKVF LGVLKPQHQA SIILETVPFK SGQRQIQANM RSNKFKDIKG YRNVYVDFAL
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