Progonadoliberin-2 (GNRH2)

About Progonadoliberin-2

Progonadoliberin-2 (GNRH2) is a protein from Homo sapiens identified by UniProt accession O43555, 120 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.

Target properties

Protein name	Progonadoliberin-2
UniProt accession	O43555
Gene	GNRH2
Organism	Homo sapiens
Length	120 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (57)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.23
cutaneous melanoma · score 0.18
gastric adenocarcinoma · score 0.11
oxytocin measurement · score 0.08
leukocyte count · score 0.05
neutrophil count · score 0.05
endometriosis · score 0.03
reticulocyte measurement · score 0.03
body mass index · score 0.03
reticulocyte count · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43555-F1	alphafold	PREDICTED	64.32	—

Amino-acid sequence (120 residues)

MASSRRGLLL LLLLTAHLGP SEAQHWSHGW YPGGKRALSS AQDPQNALRP PGRALDTAAG SPVQTAHGLP SDALAPLDDS MPWEGRTTAQ WSLHRKRHLA RTLLTAAREP RPAPPSSNKV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards