Epsilon-sarcoglycan (SGCE)

About Epsilon-sarcoglycan

Epsilon-sarcoglycan (SGCE) is a protein from Homo sapiens identified by UniProt accession O43556, 437 residues long. MolForge cross-references it against 0 known binders and 165 disease associations.

Target properties

Protein name	Epsilon-sarcoglycan
UniProt accession	O43556
Gene	SGCE
Organism	Homo sapiens
Length	437 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (165)

Diseases linked to this target (Open Targets).

myoclonus-dystonia syndrome · score 0.67
genetic disorder · score 0.47
schizophrenia · score 0.27
movement disorder · score 0.27
breast carcinoma · score 0.26
insomnia measurement · score 0.08
Unverricht-Lundborg disease · score 0.07
Progressive myoclonic epilepsy · score 0.07
Familial cortical myoclonus · score 0.07
myoclonus-cerebellar ataxia-deafness syndrome · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43556-F1	alphafold	PREDICTED	74.23	—

Amino-acid sequence (437 residues)

MQLPRWWELG DPCAWTGQGR GTRRMSPATT GTFLLTVYSI FSKVHSDRNV YPSAGVLFVH VLEREYFKGE FPPYPKPGEI SNDPITFNTN LMGYPDRPGW LRYIQRTPYS DGVLYGSPTA ENVGKPTIIE ITAYNRRTFE TARHNLIINI MSAEDFPLPY QAEFFIKNMN VEEMLASEVL GDFLGAVKNV WQPERLNAIN ITSALDRGGR VPLPINDLKE GVYVMVGADV PFSSCLREVE NPQNQLRCSQ EMEPVITCDK KFRTQFYIDW CKISLVDKTK QVSTYQEVIR GEGILPDGGE YKPPSDSLKS RDYYTDFLIT LAVPSAVALV LFLILAYIMC CRREGVEKRN MQTPDIQLVH HSAIQKSTKE LRDMSKNREI AWPLSTLPVF HPVTGEIIPP LHTDNYDSTN MPLMQTQQNL PHQTQIPQQQ TTGKWYP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards