Fibroblast growth factor receptor substrate 3 (FRS3)

About Fibroblast growth factor receptor substrate 3

Fibroblast growth factor receptor substrate 3 (FRS3) is a protein from Homo sapiens identified by UniProt accession O43559, 492 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	Fibroblast growth factor receptor substrate 3
UniProt accession	O43559
Gene	FRS3
Organism	Homo sapiens
Length	492 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

cancer · score 0.47
neurodegenerative disease · score 0.43
mean corpuscular volume · score 0.36
thyroid gland adenocarcinoma · score 0.30
breast adenocarcinoma · score 0.29
cutaneous melanoma · score 0.29
endometrial cancer · score 0.29
head and neck squamous cell carcinoma · score 0.27
mean corpuscular hemoglobin · score 0.22
body mass index · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43559-F1	alphafold	PREDICTED	56.41	—

Amino-acid sequence (492 residues)

MGSCCSCLNR DSVPDNHPTK FKVTNVDDEG VELGSGVMEL TQSELVLHLH RREAVRWPYL CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CSRAEEIFNL LQDLMQCNSI NVMEEPVIIT RNSHPAELDL PRAPQPPNAL GYTVSSFSNG CPGEGPRFSA PRRLSTSSLR HPSLGEESTH ALIAPDEQSH TYVNTPASED DHRRGRHCLQ PLPEGQAPFL PQARGPDQRD PQVFLQPGQV KFVLGPTPAR RHMVKCQGLC PSLHDPPHHN NNNEAPSECP AQPKCTYENV TGGLWRGAGW RLSPEEPGWN GLAHRRAALL HYENLPPLPP VWESQAQQLG GEAGDDGDSR DGLTPSSNGF PDGEEDETPL QKPTSTRAAI RSHGSFPVPL TRRRGSPRVF NFDFRRPGPE PPRQLNYIQV ELKGWGGDRP KGPQNPSSPQ APMPTTHPAR SSDSYAVIDL KKTVAMSNLQ RALPRDDGTA RKTRHNSTDL PL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards