Linker for activation of T-cells family member 1 (LAT)

About Linker for activation of T-cells family member 1

Linker for activation of T-cells family member 1 (LAT) is a protein from Homo sapiens identified by UniProt accession O43561, 262 residues long. MolForge cross-references it against 0 known binders and 365 disease associations.

Target properties

Protein name	Linker for activation of T-cells family member 1
UniProt accession	O43561
Gene	LAT
Organism	Homo sapiens
Length	262 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (365)

Diseases linked to this target (Open Targets).

severe combined immunodeficiency due to LAT deficiency · score 0.73
breast adenocarcinoma · score 0.29
lymphocyte count · score 0.21
neuroinflammatory disorder · score 0.19
self reported educational attainment · score 0.19
head and neck squamous cell carcinoma · score 0.12
cognitive function measurement · score 0.12
lung adenocarcinoma · score 0.10
total blood protein measurement · score 0.10
Okt4 epitope deficiency · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43561-F1	alphafold	PREDICTED	59.35	—

Amino-acid sequence (262 residues)

MEEAILVPCV LGLLLLPILA MLMALCVHCH RLPGSYDSTS SDSLYPRGIQ FKRPHTVAPW PPAYPPVTSY PPLSQPDLLP IPRSPQPLGG SHRTPSSRRD SDGANSVASY ENEGASGIRG AQAGWGVWGP SWTRLTPVSL PPEPACEDAD EDEDDYHNPG YLVVLPDSTP ATSTAAPSAP ALSTPGIRDS AFSMESIDDY VNVPESGESA EASLDGSREY VNVSQELHPG AAKTEPAALS SQEAEEVEEE GAPDYENLQE LN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards