Regulator of G-protein signaling 14 (RGS14)

About Regulator of G-protein signaling 14

Regulator of G-protein signaling 14 (RGS14) is a protein from Homo sapiens identified by UniProt accession O43566, 566 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.

Target properties

Protein name	Regulator of G-protein signaling 14
UniProt accession	O43566
Gene	RGS14
Organism	Homo sapiens
Length	566 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (82)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.35
eosinophil count · score 0.32
nephrolithiasis · score 0.31
calcium measurement · score 0.30
inflammatory bowel disease · score 0.30
erythrocyte count · score 0.30
hemoglobin measurement · score 0.30
glomerular filtration rate · score 0.29
hematocrit · score 0.29
urolithiasis · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43566-F1	alphafold	PREDICTED	67.20	—

Amino-acid sequence (566 residues)

MPGKPKHLGV PNGRMVLAVS DGELSSTTGP QGQGEGRGSS LSIHSLPSGP SSPFPTEEQP VASWALSFER LLQDPLGLAY FTEFLKKEFS AENVTFWKAC ERFQQIPASD TQQLAQEARN IYQEFLSSQA LSPVNIDRQA WLGEEVLAEP RPDMFRAQQL QIFNLMKFDS YARFVKSPLY RECLLAEAEG RPLREPGSSR LGSPDATRKK PKLKPGKSLP LGVEELGQLP PVEGPGGRPL RKSFRRELGG TANAALRRES QGSLNSSASL DLGFLAFVSS KSESHRKSLG STEGESESRP GKYCCVYLPD GTASLALARP GLTIRDMLAG ICEKRGLSLP DIKVYLVGNE QALVLDQDCT VLADQEVRLE NRITFELELT ALERVVRISA KPTKRLQEAL QPILEKHGLS PLEVVLHRPG EKQPLDLGKL VSSVAAQRLV LDTLPGVKIS KARDKSPCRS QGCPPRTQDK ATHPPPASPS SLVKVPSSAT GKRQTCDIEG LVELLNRVQS SGAHDQRGLL RKEDLVLPEF LQLPAQGPSS EETPPQTKSA AQPIGGSLNS TTDSAL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards