E3 ubiquitin-protein ligase RNF13 (RNF13)

About E3 ubiquitin-protein ligase RNF13

E3 ubiquitin-protein ligase RNF13 (RNF13) is a protein from Homo sapiens identified by UniProt accession O43567, 381 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase RNF13
UniProt accession	O43567
Gene	RNF13
Organism	Homo sapiens
Length	381 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (65)

Diseases linked to this target (Open Targets).

developmental and epileptic encephalopathy · score 0.48
smoking status measurement · score 0.26
myocardial infarction · score 0.23
attention deficit hyperactivity disorder · score 0.23
antisocial behaviour measurement · score 0.23
substance abuse · score 0.23
diet measurement · score 0.22
pulse pressure measurement · score 0.20
neoplasm · score 0.08
hepatocellular carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43567-F1	alphafold	PREDICTED	74.44	—

Amino-acid sequence (381 residues)

MLLSIGMLML SATQVYTILT VQLFAFLNLL PVEADILAYN FENASQTFDD LPARFGYRLP AEGLKGFLIN SKPENACEPI VPPPVKDNSS GTFIVLIRRL DCNFDIKVLN AQRAGYKAAI VHNVDSDDLI SMGSNDIEVL KKIDIPSVFI GESSANSLKD EFTYEKGGHL ILVPEFSLPL EYYLIPFLII VGICLILIVI FMITKFVQDR HRARRNRLRK DQLKKLPVHK FKKGDEYDVC AICLDEYEDG DKLRILPCSH AYHCKCVDPW LTKTKKTCPV CKQKVVPSQG DSDSDTDSSQ EENEVTEHTP LLRPLASVSA QSFGALSESR SHQNMTESSD YEEDDNEDTD SSDAENEINE HDVVVQLQPN GERDYNIANT V

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards