About A-kinase anchor protein 10, mitochondrial
A-kinase anchor protein 10, mitochondrial (AKAP10) is a protein
from Homo sapiens identified by UniProt accession
O43572, 662 residues long.
MolForge cross-references it against 0 known binders and
182 disease associations.
Target properties
| Protein name | A-kinase anchor protein 10, mitochondrial |
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| UniProt accession | O43572 |
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| Gene | AKAP10 |
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| Organism | Homo sapiens |
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| Length | 662 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (182)
Diseases linked to this target (Open Targets).
- platelet count · score 0.37
- neurodegenerative disease · score 0.37
- neutrophil count · score 0.35
- mean platelet volume · score 0.35
- cortical thickness · score 0.29
- physical activity measurement · score 0.28
- IGF-1 measurement · score 0.28
- cortical surface area measurement · score 0.28
- brain volume measurement · score 0.27
- brain measurement · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43572-F1 | alphafold | PREDICTED | 64.25 | — |
Amino-acid sequence (662 residues)
MRGAGPSPRQ SPRTLRPDPG PAMSFFRRKV KGKEQEKTSD VKSIKASISV HSPQKSTKNH ALLEAAGPSH VAINAISANM DSFSSSRTAT LKKQPSHMEA AHFGDLGRSC LDYQTQETKS SLSKTLEQVL HDTIVLPYFI QFMELRRMEH LVKFWLEAES FHSTTWSRIR AHSLNTVKQS SLAEPVSPSK KHETTASFLT DSLDKRLEDS GSAQLFMTHS EGIDLNNRTN STQNHLLLSQ ECDSAHSLRL EMARAGTHQV SMETQESSST LTVASRNSPA SPLKELSGKL MKSIEQDAVN TFTKYISPDA AKPIPITEAM RNDIIARICG EDGQVDPNCF VLAQSIVFSA MEQEHFSEFL RSHHFCKYQI EVLTSGTVYL ADILFCESAL FYFSEYMEKE DAVNILQFWL AADNFQSQLA AKKGQYDGQE AQNDAMILYD KYFSLQATHP LGFDDVVRLE IESNICREGG PLPNCFTTPL RQAWTTMEKV FLPGFLSSNL YYKYLNDLIH SVRGDEFLGG NVSLTAPGSV GPPDESHPGS SDSSASQSSV KKASIKILKN FDEAIIVDAA SLDPESLYQR TYAGKMTFGR VSDLGQFIRE SEPEPDVRKS KGSMFSQAMK KWVQGNTDEA QEELAWKIAK MIVSDIMQQA QYDQPLEKST KL
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