About Density-regulated protein
Density-regulated protein (DENR) is a protein
from Homo sapiens identified by UniProt accession
O43583, 198 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | Density-regulated protein |
|---|
| UniProt accession | O43583 |
|---|
| Gene | DENR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 198 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (39)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- apolipoprotein A 1 measurement · score 0.14
- neoplasm · score 0.08
- isolated asymptomatic elevation of creatine phosphokinase · score 0.07
- pentosuria · score 0.05
- cancer · score 0.03
- body height · score 0.03
- appendicular lean mass · score 0.02
- mean platelet volume · score 0.02
- infection · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43583-F1 | alphafold | PREDICTED | 62.49 | — |
Amino-acid sequence (198 residues)
MAADISESSG ADCKGDPRNS AKLDADYPLR VLYCGVCSLP TEYCEYMPDV AKCRQWLEKN FPNEFAKLTV ENSPKQEAGI SEGQGTAGEE EEKKKQKRGG RGQIKQKKKT VPQKVTIAKI PRAKKKYVTR VCGLATFEID LKEAQRFFAQ KFSCGASVTG EDEIIIQGDF TDDIIDVIQE KWPEVDDDSI EDLGEVKK
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