About Proline-serine-threonine phosphatase-interacting protein 1
Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) is a protein
from Homo sapiens identified by UniProt accession
O43586, 416 residues long.
MolForge cross-references it against 0 known binders and
168 disease associations.
Target properties
| Protein name | Proline-serine-threonine phosphatase-interacting protein 1 |
|---|
| UniProt accession | O43586 |
|---|
| Gene | PSTPIP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 416 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (168)
Diseases linked to this target (Open Targets).
- pyogenic arthritis-pyoderma gangrenosum-acne syndrome · score 0.78
- Pyogenic arthritis - pyoderma gangrenosum - acne · score 0.77
- Behcet's syndrome · score 0.45
- platelet count · score 0.45
- neutrophil count · score 0.43
- self reported educational attainment · score 0.42
- myeloid white cell count · score 0.38
- Recurrent infections - inflammatory syndrome due to zinc metabolism disorder · score 0.37
- recurrent infections-inflammatory syndrome due to zinc metabolism disorder syndrome · score 0.37
- body height · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43586-F1 | alphafold | PREDICTED | 85.73 | — |
Amino-acid sequence (416 residues)
MMPQLQFKDA FWCRDFTAHT GYEVLLQRLL DGRKMCKDME ELLRQRAQAE ERYGKELVQI ARKAGGQTEI NSLRASFDSL KQQMENVGSS HIQLALTLRE ELRSLEEFRE RQKEQRKKYE AVMDRVQKSK LSLYKKAMES KKTYEQKCRD ADDAEQAFER ISANGHQKQV EKSQNKARQC KDSATEAERV YRQSIAQLEK VRAEWEQEHR TTCEAFQLQE FDRLTILRNA LWVHSNQLSM QCVKDDELYE EVRLTLEGCS IDADIDSFIQ AKSTGTEPPA PVPYQNYYDR EVTPLTSSPG IQPSCGMIKR FSGLLHGSPK TTSLAASAAS TETLTPTPER NEGVYTAIAV QEIQGNPASP AQEYRALYDY TAQNPDELDL SAGDILEVIL EGEDGWWTVE RNGQRGFVPG SYLEKL
Explore Proline-serine-threonine phosphatase-interacting protein 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets