5-hydroxymethyl-dUMP N-hydrolase (DNPH1)

About 5-hydroxymethyl-dUMP N-hydrolase

5-hydroxymethyl-dUMP N-hydrolase (DNPH1) is a protein from Homo sapiens identified by UniProt accession O43598, 174 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	5-hydroxymethyl-dUMP N-hydrolase
UniProt accession	O43598
Gene	DNPH1
Organism	Homo sapiens
Length	174 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (23)

Diseases linked to this target (Open Targets).

risk-taking behaviour · score 0.16
intelligence · score 0.10
insomnia · score 0.09
waist-hip ratio · score 0.07
schizophrenia · score 0.06
cognitive function measurement · score 0.06
forced expiratory volume · score 0.05
vital capacity · score 0.05
mean corpuscular hemoglobin concentration · score 0.04
erythrocyte count · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43598-F1	alphafold	PREDICTED	85.38	—

Amino-acid sequence (174 residues)

MAAAMVPGRS ESWERGEPGR PALYFCGSIR GGREDRTLYE RIVSRLRRFG TVLTEHVAAA ELGARGEEAA GGDRLIHEQD LEWLQQADVV VAEVTQPSLG VGYELGRAVA FNKRILCLFR PQSGRVLSAM IRGAADGSRF QVWDYEEGEV EALLDRYFEA DPPGQVAASP DPTT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards