Neuronal migration protein doublecortin (DCX)

About Neuronal migration protein doublecortin

Neuronal migration protein doublecortin (DCX) is a protein from Homo sapiens identified by UniProt accession O43602, 365 residues long. MolForge cross-references it against 0 known binders and 346 disease associations.

Target properties

Protein name	Neuronal migration protein doublecortin
UniProt accession	O43602
Gene	DCX
Organism	Homo sapiens
Length	365 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (346)

Diseases linked to this target (Open Targets).

lissencephaly type 1 due to doublecortin gene mutation · score 0.86
subcortical band heterotopia · score 0.63
Non-syndromic cerebral malformation due to abnormal neuronal migration · score 0.56
Abnormal cortical gyration · score 0.52
genetic disorder · score 0.51
Neurodevelopmental disorder · score 0.37
lissencephaly spectrum disorders · score 0.37
Lissencephaly · score 0.36
Abnormality of the nervous system · score 0.34
fucosidosis · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43602-F1	alphafold	PREDICTED	66.49	—

Amino-acid sequence (365 residues)

MELDFGHFDE RDKTSRNMRG SRMNGLPSPT HSAHCSFYRT RTLQALSNEK KAKKVRFYRN GDRYFKGIVY AVSSDRFRSF DALLADLTRS LSDNINLPQG VRYIYTIDGS RKIGSMDELE EGESYVCSSD NFFKKVEYTK NVNPNWSVNV KTSANMKAPQ SLASSNSAQA RENKDFVRPK LVTIIRSGVK PRKAVRVLLN KKTAHSFEQV LTDITEAIKL ETGVVKKLYT LDGKQVTCLH DFFGDDDVFI ACGPEKFRYA QDDFSLDENE CRVMKGNPSA TAGPKASPTP QKTSAKSPGP MRRSKSPADS GNDQDANGTS SSQLSTPKSK QSPISTPTSP GSLRKHKDLY LPLSLDDSDS LGDSM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards