Galanin receptor type 2 (GALR2)

About Galanin receptor type 2

Galanin receptor type 2 (GALR2) is a protein from Homo sapiens identified by UniProt accession O43603, 387 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.

Target properties

Protein name	Galanin receptor type 2
UniProt accession	O43603
Gene	GALR2
Organism	Homo sapiens
Length	387 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (106)

Diseases linked to this target (Open Targets).

head and neck squamous cell carcinoma · score 0.18
breast adenocarcinoma · score 0.17
neoplasm · score 0.10
plasma fibronectin deficiency · score 0.07
isolated asymptomatic elevation of creatine phosphokinase · score 0.06
mononeuropathy · score 0.05
colitis · score 0.05
diabetic nephropathy · score 0.04
Hereditary persistence of alpha-fetoprotein · score 0.04
neutropenia, severe congenital, 2, autosomal dominant · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43603-F1	alphafold	PREDICTED	77.93	—

Amino-acid sequence (387 residues)

MNVSGCPGAG NASQAGGGGG WHPEAVIVPL LFALIFLVGT VGNTLVLAVL LRGGQAVSTT NLFILNLGVA DLCFILCCVP FQATIYTLDG WVFGSLLCKA VHFLIFLTMH ASSFTLAAVS LDRYLAIRYP LHSRELRTPR NALAAIGLIW GLSLLFSGPY LSYYRQSQLA NLTVCHPAWS APRRRAMDIC TFVFSYLLPV LVLGLTYART LRYLWRAVDP VAAGSGARRA KRKVTRMILI VAALFCLCWM PHHALILCVW FGQFPLTRAT YALRILSHLV SYANSCVNPI VYALVSKHFR KGFRTICAGL LGRAPGRASG RVCAAARGTH SGSVLERESS DLLHMSEAAG ALRPCPGASQ PCILEPCPGP SWQGPKAGDS ILTVDVA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards