Hypocretin neuropeptide precursor (HCRT)

About Hypocretin neuropeptide precursor

Hypocretin neuropeptide precursor (HCRT) is a protein from Homo sapiens identified by UniProt accession O43612, 131 residues long. MolForge cross-references it against 0 known binders and 424 disease associations.

Target properties

Protein name	Hypocretin neuropeptide precursor
UniProt accession	O43612
Gene	HCRT
Organism	Homo sapiens
Length	131 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (424)

Diseases linked to this target (Open Targets).

narcolepsy-cataplexy syndrome · score 0.36
breast adenocarcinoma · score 0.25
neuroinflammatory disorder · score 0.23
lung adenocarcinoma · score 0.19
Cataplexy · score 0.10
Narcolepsy · score 0.10
narcolepsy · score 0.10
neoplasm · score 0.09
experimental autoimmune encephalomyelitis · score 0.08
major depressive disorder · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43612-F1	alphafold	PREDICTED	60.64	—

Amino-acid sequence (131 residues)

MNLPSTKVSW AAVTLLLLLL LLPPALLSSG AAAQPLPDCC RQKTCSCRLY ELLHGAGNHA AGILTLGKRR SGPPGLQGRL QRLLQASGNH AAGILTMGRR AGAEPAPRPC LGRRCSAPAA ASVAPGGQSG I

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards