Orexin/Hypocretin receptor type 1 (HCRTR1)

About Orexin/Hypocretin receptor type 1

Orexin/Hypocretin receptor type 1 (HCRTR1) is a protein from Homo sapiens identified by UniProt accession O43613, 425 residues long. MolForge cross-references it against 0 known binders and 183 disease associations.

Target properties

Protein name	Orexin/Hypocretin receptor type 1
UniProt accession	O43613
Gene	HCRTR1
Organism	Homo sapiens
Length	425 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (5)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (183)

Diseases linked to this target (Open Targets).

insomnia · score 0.59
Sleep Disorder · score 0.50
post-traumatic stress disorder · score 0.40
panic disorder · score 0.37
intelligence · score 0.36
FEV/FVC ratio · score 0.33
cognitive function measurement · score 0.32
self reported educational attainment · score 0.30
alcohol dependence · score 0.28
delirium · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43613-F1	alphafold	PREDICTED	78.81	—

Amino-acid sequence (425 residues)

MEPSATPGAQ MGVPPGSREP SPVPPDYEDE FLRYLWRDYL YPKQYEWVLI AAYVAVFVVA LVGNTLVCLA VWRNHHMRTV TNYFIVNLSL ADVLVTAICL PASLLVDITE SWLFGHALCK VIPYLQAVSV SVAVLTLSFI ALDRWYAICH PLLFKSTARR ARGSILGIWA VSLAIMVPQA AVMECSSVLP ELANRTRLFS VCDERWADDL YPKIYHSCFF IVTYLAPLGL MAMAYFQIFR KLWGRQIPGT TSALVRNWKR PSDQLGDLEQ GLSGEPQPRA RAFLAEVKQM RARRKTAKML MVVLLVFALC YLPISVLNVL KRVFGMFRQA SDREAVYACF TFSHWLVYAN SAANPIIYNF LSGKFREQFK AAFSCCLPGL GPCGSLKAPS PRSSASHKSL SLQSRCSISK ISEHVVLTSV TTVLP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards