Orexin receptor type 2 (HCRTR2)

About Orexin receptor type 2

Orexin receptor type 2 (HCRTR2) is a protein from Homo sapiens identified by UniProt accession O43614, 444 residues long. MolForge cross-references it against 0 known binders and 127 disease associations.

Target properties

Protein name	Orexin receptor type 2
UniProt accession	O43614
Gene	HCRTR2
Organism	Homo sapiens
Length	444 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (127)

Diseases linked to this target (Open Targets).

insomnia · score 0.59
Sleep Disorder · score 0.51
sleep duration · score 0.44
blood urea nitrogen measurement · score 0.43
circadian rhythm · score 0.42
chronotype measurement · score 0.41
post-traumatic stress disorder · score 0.40
excessive daytime sleepiness measurement · score 0.39
hemoglobin measurement · score 0.38
hematocrit · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43614-F1	alphafold	PREDICTED	78.96	—

Amino-acid sequence (444 residues)

MSGTKLEDSP PCRNWSSASE LNETQEPFLN PTDYDDEEFL RYLWREYLHP KEYEWVLIAG YIIVFVVALI GNVLVCVAVW KNHHMRTVTN YFIVNLSLAD VLVTITCLPA TLVVDITETW FFGQSLCKVI PYLQTVSVSV SVLTLSCIAL DRWYAICHPL MFKSTAKRAR NSIVIIWIVS CIIMIPQAIV MECSTVFPGL ANKTTLFTVC DERWGGEIYP KMYHICFFLV TYMAPLCLMV LAYLQIFRKL WCRQIPGTSS VVQRKWKPLQ PVSQPRGPGQ PTKSRMSAVA AEIKQIRARR KTARMLMIVL LVFAICYLPI SILNVLKRVF GMFAHTEDRE TVYAWFTFSH WLVYANSAAN PIIYNFLSGK FREEFKAAFS CCCLGVHHRQ EDRLTRGRTS TESRKSLTTQ ISNFDNISKL SEQVVLTSIS TLPAANGAGP LQNW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards