About Mitochondrial import inner membrane translocase subunit TIM44
Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) is a protein
from Homo sapiens identified by UniProt accession
O43615, 452 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Mitochondrial import inner membrane translocase subunit TIM44 |
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| UniProt accession | O43615 |
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| Gene | TIMM44 |
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| Organism | Homo sapiens |
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| Length | 452 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (26)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.43
- multiple sclerosis · score 0.37
- Parkinson disease · score 0.37
- lysosomal storage disease · score 0.37
- Alzheimer disease · score 0.37
- urinary bladder carcinoma · score 0.07
- cancer · score 0.03
- sitting height measurement · score 0.03
- C-reactive protein measurement · score 0.02
- serum alanine aminotransferase measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43615-F1 | alphafold | PREDICTED | 63.92 | — |
Amino-acid sequence (452 residues)
MAAAALRSGW CRCPRRCLGS GIQFLSSHNL PHGSTYQMRR PGGELPLSKS YSSGNRKGFL SGLLDNVKQE LAKNKEMKES IKKFRDEARR LEESDVLQEA RRKYKTIESE TVRTSEVLRK KLGELTGTVK ESLHEVSKSD LGRKIKEGVE EAAKTAKQSA ESVSKGGEKL GRTAAFRALS QGVESVKKEI DDSVLGQTGP YRRPQRLRKR TEFAGDKFKE EKVFEPNEEA LGVVLHKDSK WYQQWKDFKE NNVVFNRFFE MKMKYDESDN AFIRASRALT DKVTDLLGGL FSKTEMSEVL TEILRVDPAF DKDRFLKQCE NDIIPNVLEA MISGELDILK DWCYEATYSQ LAHPIQQAKA LGLQFHSRIL DIDNVDLAMG KMMEQGPVLI ITFQAQLVMV VRNPKGEVVE GDPDKVLRML YVWALCRDQD ELNPYAAWRL LDISASSTEQ IL
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