Trafficking protein particle complex subunit 3…

About Trafficking protein particle complex subunit 3

Trafficking protein particle complex subunit 3 (TRAPPC3) is a protein from Homo sapiens identified by UniProt accession O43617, 180 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Trafficking protein particle complex subunit 3
UniProt accession	O43617
Gene	TRAPPC3
Organism	Homo sapiens
Length	180 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.55
multiple sclerosis · score 0.33
lysosomal storage disease · score 0.33
Parkinson disease · score 0.33
Alzheimer disease · score 0.33
Bardet-Biedl syndrome · score 0.26
lean body mass · score 0.07
body weight · score 0.06
base metabolic rate measurement · score 0.04
PR interval · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43617-F1	alphafold	PREDICTED	90.57	—

Amino-acid sequence (180 residues)

MSRQANRGTE SKKMSSELFT LTYGALVTQL CKDYENDEDV NKQLDKMGFN IGVRLIEDFL ARSNVGRCHD FRETADVIAK VAFKMYLGIT PSITNWSPAG DEFSLILENN PLVDFVELPD NHSSLIYSNL LCGVLRGALE MVQMAVEAKF VQDTLKGDGV TEIRMRFIRR IEDNLPAGEE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Trafficking protein particle complex subunit 3 (TRAPPC3)