Prostate stem cell antigen (PSCA)

About Prostate stem cell antigen

Prostate stem cell antigen (PSCA) is a protein from Homo sapiens identified by UniProt accession O43653, 114 residues long. MolForge cross-references it against 0 known binders and 128 disease associations.

Target properties

Protein name	Prostate stem cell antigen
UniProt accession	O43653
Gene	PSCA
Organism	Homo sapiens
Length	114 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (128)

Diseases linked to this target (Open Targets).

gastric carcinoma · score 0.30
duodenal ulcer · score 0.24
urinary bladder carcinoma · score 0.24
gastric cancer · score 0.20
atrophic gastritis · score 0.20
body mass index · score 0.20
urinary bladder cancer · score 0.20
gastric ulcer · score 0.20
Malignant Urinary System Neoplasm · score 0.19
body fat percentage · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43653-F1	alphafold	PREDICTED	81.32	—

Amino-acid sequence (114 residues)

MAGLALQPGT ALLCYSCKAQ VSNEDCLQVE NCTQLGEQCW TARIRAVGLL TVISKGCSLN CVDDSQDYYV GKKNITCCDT DLCNASGAHA LQPAAAILAL LPALGLLLWG PGQL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards