About Tetraspanin-6
Tetraspanin-6 (TSPAN6) is a protein
from Homo sapiens identified by UniProt accession
O43657, 245 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Target properties
| Protein name | Tetraspanin-6 |
|---|
| UniProt accession | O43657 |
|---|
| Gene | TSPAN6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 245 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (56)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.09
- specific language impairment · score 0.09
- glioblastoma · score 0.07
- 7q11.23 microduplication syndrome · score 0.07
- Monoamine oxidase A deficiency · score 0.07
- microangiopathy and leukoencephalopathy, pontine, autosomal dominant · score 0.05
- pancreatic neoplasm · score 0.05
- cancer · score 0.04
- ependymoma · score 0.02
- non-small cell lung carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43657-F1 | alphafold | PREDICTED | 88.32 | — |
Amino-acid sequence (245 residues)
MASPSRRLQT KPVITCFKSV LLIYTFIFWI TGVILLAVGI WGKVSLENYF SLLNEKATNV PFVLIATGTV IILLGTFGCF ATCRASAWML KLYAMFLTLV FLVELVAAIV GFVFRHEIKN SFKNNYEKAL KQYNSTGDYR SHAVDKIQNT LHCCGVTDYR DWTDTNYYSE KGFPKSCCKL EDCTPQRDAD KVNNEGCFIK VMTIIESEMG VVAGISFGVA CFQLIGIFLA YCLSRAITNN QYEIV
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