About Pleiotropic regulator 1
Pleiotropic regulator 1 (PLRG1) is a protein
from Homo sapiens identified by UniProt accession
O43660, 514 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Pleiotropic regulator 1 |
|---|
| UniProt accession | O43660 |
|---|
| Gene | PLRG1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 514 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (35)
Diseases linked to this target (Open Targets).
- Alzheimer disease · score 0.46
- Parkinson disease · score 0.46
- multiple sclerosis · score 0.46
- neurodegenerative disease · score 0.46
- lysosomal storage disease · score 0.46
- Ischemic stroke · score 0.18
- fibrinogen measurement · score 0.18
- blood protein measurement · score 0.18
- cancer · score 0.08
- neoplasm · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43660-F1 | alphafold | PREDICTED | 77.36 | — |
Amino-acid sequence (514 residues)
MVEEVQKHSV HTLVFRSLKR THDMFVADNG KPVPLDEESH KRKMAIKLRN EYGPVLHMPT SKENLKEKGP QNATDSYVHK QYPANQGQEV EYFVAGTHPY PPGPGVALTA DTKIQRMPSE SAAQSLAVAL PLQTKADANR TAPSGSEYRH PGASDRPQPT AMNSIVMETG NTKNSALMAK KAPTMPKPQW HPPWKLYRVI SGHLGWVRCI AVEPGNQWFV TGSADRTIKI WDLASGKLKL SLTGHISTVR GVIVSTRSPY LFSCGEDKQV KCWDLEYNKV IRHYHGHLSA VYGLDLHPTI DVLVTCSRDS TARIWDVRTK ASVHTLSGHT NAVATVRCQA AEPQIITGSH DTTIRLWDLV AGKTRVTLTN HKKSVRAVVL HPRHYTFASG SPDNIKQWKF PDGSFIQNLS GHNAIINTLT VNSDGVLVSG ADNGTMHLWD WRTGYNFQRV HAAVQPGSLD SESGIFACAF DQSESRLLTA EADKTIKVYR EDDTATEETH PVSWKPEIIK RKRF
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