About Protein regulator of cytokinesis 1
Protein regulator of cytokinesis 1 (PRC1) is a protein
from Homo sapiens identified by UniProt accession
O43663, 620 residues long.
MolForge cross-references it against 0 known binders and
272 disease associations.
Target properties
| Protein name | Protein regulator of cytokinesis 1 |
|---|
| UniProt accession | O43663 |
|---|
| Gene | PRC1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 620 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (272)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- breast carcinoma · score 0.50
- Red cell distribution width · score 0.42
- mean platelet volume · score 0.38
- type 2 diabetes mellitus · score 0.38
- platelet count · score 0.38
- lysosomal storage disease · score 0.31
- platelet component distribution width · score 0.31
- Drugs used in diabetes use measurement · score 0.29
- checkup · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43663-F1 | alphafold | PREDICTED | 78.95 | — |
Amino-acid sequence (620 residues)
MRRSEVLAEE SIVCLQKALN HLREIWELIG IPEDQRLQRT EVVKKHIKEL LDMMIAEEES LKERLIKSIS VCQKELNTLC SELHVEPFQE EGETTILQLE KDLRTQVELM RKQKKERKQE LKLLQEQDQE LCEILCMPHY DIDSASVPSL EELNQFRQHV TTLRETKASR REEFVSIKRQ IILCMEALDH TPDTSFERDV VCEDEDAFCL SLENIATLQK LLRQLEMQKS QNEAVCEGLR TQIRELWDRL QIPEEEREAV ATIMSGSKAK VRKALQLEVD RLEELKMQNM KKVIEAIRVE LVQYWDQCFY SQEQRQAFAP FCAEDYTESL LQLHDAEIVR LKNYYEVHKE LFEGVQKWEE TWRLFLEFER KASDPNRFTN RGGNLLKEEK QRAKLQKMLP KLEEELKARI ELWEQEHSKA FMVNGQKFME YVAEQWEMHR LEKERAKQER QLKNKKQTET EMLYGSAPRT PSKRRGLAPN TPGKARKLNT TTMSNATANS SIRPIFGGTV YHSPVSRLPP SGSKPVAAST CSGKKTPRTG RHGANKENLE LNGSILSGGY PGSAPLQRNF SINSVASTYS EFAKDPSLSD SSTVGLQREL SKASKSDATS GILNSTNIQS
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