About BUB3-interacting and GLEBS motif-containing protein ZNF207
BUB3-interacting and GLEBS motif-containing protein ZNF207 (ZNF207) is a protein
from Homo sapiens identified by UniProt accession
O43670, 478 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | BUB3-interacting and GLEBS motif-containing protein ZNF207 |
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| UniProt accession | O43670 |
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| Gene | ZNF207 |
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| Organism | Homo sapiens |
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| Length | 478 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (70)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.56
- Parkinson disease · score 0.46
- multiple sclerosis · score 0.46
- Alzheimer disease · score 0.46
- lysosomal storage disease · score 0.46
- systolic blood pressure · score 0.23
- smoking status measurement · score 0.21
- schizophrenia · score 0.19
- antisocial behaviour measurement · score 0.17
- substance abuse · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43670-F1 | alphafold | PREDICTED | 59.93 | — |
Amino-acid sequence (478 residues)
MGRKKKKQLK PWCWYCNRDF DDEKILIQHQ KAKHFKCHIC HKKLYTGPGL AIHCMQVHKE TIDAVPNAIP GRTDIELEIY GMEGIPEKDM DERRRLLEQK TQESQKKKQQ DDSDEYDDDD SAASTSFQPQ PVQPQQGYIP PMAQPGLPPV PGAPGMPPGI PPLMPGVPPL MPGMPPVMPG MPPGMMPMGG MMPPGPGIPP LMPGMPPGMP PPVPRPGIPP MTQAQAVSAP GILNRPPAPT ATVPAPQPPV TKPLFPSAGQ MGTPVTSSST ASSNSESLSA SSKALFPSTA QAQAAVQGPV GTDFKPLNST PATTTEPPKP TFPAYTQSTA STTSTTNSTA AKPAASITSK PATLTTTSAT SKLIHPDEDI SLEERRAQLP KYQRNLPRPG QAPIGNPPVG PIGGMMPPQP GIPQQQGMRP PMPPHGQYGG HHQGMPGYLP GAMPPYGQGP PMVPPYQGGP PRPPMGMRPP VMSQGGRY
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