NADH dehydrogenase [ubiquinone] 1 beta subcomplex…

About NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (NDUFB5) is a protein from Homo sapiens identified by UniProt accession O43674, 189 residues long. MolForge cross-references it against 0 known binders and 228 disease associations.

Target properties

Protein name	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
UniProt accession	O43674
Gene	NDUFB5
Organism	Homo sapiens
Length	189 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (228)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.61
diabetes mellitus · score 0.60
polycystic ovary syndrome · score 0.60
type 1 diabetes mellitus · score 0.58
gestational diabetes · score 0.58
obesity · score 0.57
prediabetes syndrome · score 0.56
schizophrenia · score 0.55
insulin resistance · score 0.55
metabolic syndrome · score 0.53

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43674-F1	alphafold	PREDICTED	83.22	—

Amino-acid sequence (189 residues)

MAAMSLLRRV SVTAVAALSG RPLGTRLGFG GFLTRGFPKA AAPVRHSGDH GKRLFVIRPS RFYDRRFLKL LRFYIALTGI PVAIFITLVN VFIGQAELAE IPEGYVPEHW EYYKHPISRW IARNFYDSPE KIYERTMAVL QIEAEKAELR VKELEVRKLM HVRGDGPWYY YETIDKELID HSPKATPDN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (NDUFB5)