LIM domain-binding protein 2 (LDB2)

About LIM domain-binding protein 2

LIM domain-binding protein 2 (LDB2) is a protein from Homo sapiens identified by UniProt accession O43679, 373 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.

Target properties

Protein name	LIM domain-binding protein 2
UniProt accession	O43679
Gene	LDB2
Organism	Homo sapiens
Length	373 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (65)

Diseases linked to this target (Open Targets).

protein measurement · score 0.43
risky sexual behaviour measurement · score 0.33
body weight · score 0.32
body mass index · score 0.30
ulcerative colitis · score 0.29
self reported educational attainment · score 0.26
fat body mass · score 0.20
FEV/FVC ratio · score 0.14
cortical thickness · score 0.07
neoplasm · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43679-F1	alphafold	PREDICTED	72.73	—

Amino-acid sequence (373 residues)

MSSTPHDPFY SSPFGPFYRR HTPYMVQPEY RIYEMNKRLQ SRTEDSDNLW WDAFATEFFE DDATLTLSFC LEDGPKRYTI GRTLIPRYFS TVFEGGVTDL YYILKHSKES YHNSSITVDC DQCTMVTQHG KPMFTKVCTE GRLILEFTFD DLMRIKTWHF TIRQYRELVP RSILAMHAQD PQVLDQLSKN ITRMGLTNFT LNYLRLCVIL EPMQELMSRH KTYNLSPRDC LKTCLFQKWQ RMVAPPAEPT RQPTTKRRKR KNSTSSTSNS SAGNNANSTG SKKKTTAANL SLSSQVPDVM VVGEPTLMGG EFGDEDERLI TRLENTQYDA ANGMDDEEDF NNSPALGNNS PWNSKPPATQ ETKSENPPPQ ASQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards