About Transcription factor 21
Transcription factor 21 (TCF21) is a protein
from Homo sapiens identified by UniProt accession
O43680, 179 residues long.
MolForge cross-references it against 0 known binders and
247 disease associations.
Target properties
| Protein name | Transcription factor 21 |
|---|
| UniProt accession | O43680 |
|---|
| Gene | TCF21 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 179 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (247)
Diseases linked to this target (Open Targets).
- coronary artery disease · score 0.53
- myocardial infarction · score 0.50
- angina pectoris · score 0.48
- FEV/FVC ratio · score 0.47
- systolic blood pressure · score 0.44
- peak expiratory flow · score 0.44
- hematocrit · score 0.42
- neurodegenerative disease · score 0.41
- creatinine measurement · score 0.41
- Vasodilators used in cardiac diseases use measurement · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43680-F1 | alphafold | PREDICTED | 66.02 | — |
Amino-acid sequence (179 residues)
MSTGSLSDVE DLQEVEMLEC DGLKMDSNKE FVTSNESTEE SSNCENGSPQ KGRGGLGKRR KAPTKKSPLS GVSQEGKQVQ RNAANARERA RMRVLSKAFS RLKTTLPWVP PDTKLSKLDT LRLASSYIAH LRQILANDKY ENGYIHPVNL TWPFMVAGKP ESDLKEVVTA SRLCGTTAS
Explore Transcription factor 21 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets