Mitotic checkpoint protein BUB3 (BUB3)

About Mitotic checkpoint protein BUB3

Mitotic checkpoint protein BUB3 (BUB3) is a protein from Homo sapiens identified by UniProt accession O43684, 328 residues long. MolForge cross-references it against 0 known binders and 103 disease associations.

Target properties

Protein name	Mitotic checkpoint protein BUB3
UniProt accession	O43684
Gene	BUB3
Organism	Homo sapiens
Length	328 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (103)

Diseases linked to this target (Open Targets).

mosaic variegated aneuploidy syndrome · score 0.37
sleep duration · score 0.22
lung adenocarcinoma · score 0.20
endometrial cancer · score 0.18
ovarian cancer · score 0.18
alcohol consumption measurement · score 0.18
breast adenocarcinoma · score 0.18
body height · score 0.18
vital capacity · score 0.16
lung volume · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43684-F1	alphafold	PREDICTED	95.96	—

Amino-acid sequence (328 residues)

MTGSNEFKLN QPPEDGISSV KFSPNTSQFL LVSSWDTSVR LYDVPANSMR LKYQHTGAVL DCAFYDPTHA WSGGLDHQLK MHDLNTDQEN LVGTHDAPIR CVEYCPEVNV MVTGSWDQTV KLWDPRTPCN AGTFSQPEKV YTLSVSGDRL IVGTAGRRVL VWDLRNMGYV QQRRESSLKY QTRCIRAFPN KQGYVLSSIE GRVAVEYLDP SPEVQKKKYA FKCHRLKENN IEQIYPVNAI SFHNIHNTFA TGGSDGFVNI WDPFNKKRLC QFHRYPTSIA SLAFSNDGTT LAIASSYMYE MDDTEHPEDG IFIRQVTDAE TKPKSPCT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards