About Phospholipid phosphatase 2
Phospholipid phosphatase 2 (PLPP2) is a protein
from Homo sapiens identified by UniProt accession
O43688, 288 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | Phospholipid phosphatase 2 |
|---|
| UniProt accession | O43688 |
|---|
| Gene | PLPP2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 288 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (45)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.21
- neoplasm · score 0.09
- lung adenocarcinoma · score 0.08
- cancer · score 0.05
- non-small cell lung carcinoma · score 0.03
- lymphocyte percentage of leukocytes · score 0.03
- nonpapillary renal cell carcinoma · score 0.02
- Acute hepatic failure · score 0.01
- transitional cell carcinoma of kidney · score 0.01
- pancreatic adenocarcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43688-F1 | alphafold | PREDICTED | 85.79 | — |
Amino-acid sequence (288 residues)
MQRRWVFVLL DVLCLLVASL PFAILTLVNA PYKRGFYCGD DSIRYPYRPD TITHGLMAGV TITATVILVS AGEAYLVYTD RLYSRSDFNN YVAAVYKVLG TFLFGAAVSQ SLTDLAKYMI GRLRPNFLAV CDPDWSRVNC SVYVQLEKVC RGNPADVTEA RLSFYSGHSS FGMYCMVFLA LYVQARLCWK WARLLRPTVQ FFLVAFALYV GYTRVSDYKH HWSDVLVGLL QGALVAALTV CYISDFFKAR PPQHCLKEEE LERKPSLSLT LTLGEADHNH YGYPHSSS
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