Sialic acid-binding Ig-like lectin 6 (SIGLEC6)

About Sialic acid-binding Ig-like lectin 6

Sialic acid-binding Ig-like lectin 6 (SIGLEC6) is a protein from Homo sapiens identified by UniProt accession O43699, 453 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.

Target properties

Protein name	Sialic acid-binding Ig-like lectin 6
UniProt accession	O43699
Gene	SIGLEC6
Organism	Homo sapiens
Length	453 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (115)

Diseases linked to this target (Open Targets).

sialic acid-binding Ig-like lectin 6 measurement · score 0.34
blood protein measurement · score 0.32
protein measurement · score 0.25
carotid artery intima media thickness · score 0.24
prostate carcinoma · score 0.11
prostate cancer · score 0.11
Familial prostate cancer · score 0.11
chronic lymphocytic leukemia · score 0.10
MODY · score 0.07
isolated agammaglobulinemia · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43699-F1	alphafold	PREDICTED	77.32	—

Amino-acid sequence (453 residues)

MQGAQEASAS EMLPLLLPLL WAGALAQERR FQLEGPESLT VQEGLCVLVP CRLPTTLPAS YYGYGYWFLE GADVPVATND PDEEVQEETR GRFHLLWDPR RKNCSLSIRD ARRRDNAAYF FRLKSKWMKY GYTSSKLSVR VMALTHRPNI SIPGTLESGH PSNLTCSVPW VCEQGTPPIF SWMSAAPTSL GPRTTQSSVL TITPRPQDHS TNLTCQVTFP GAGVTMERTI QLNVSYAPQK VAISIFQGNS AAFKILQNTS SLPVLEGQAL RLLCDADGNP PAHLSWFQGF PALNATPISN TGVLELPQVG SAEEGDFTCR AQHPLGSLQI SLSLFVHWKP EGRAGGVLGA VWGASITTLV FLCVCFIFRV KTRRKKAAQP VQNTDDVNPV MVSGSRGHQH QFQTGIVSDH PAEAGPISED EQELHYAVLH FHKVQPQEPK VTDTEYSEIK IHK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards