About Maleylacetoacetate isomerase
Maleylacetoacetate isomerase (GSTZ1) is a protein
from Homo sapiens identified by UniProt accession
O43708, 216 residues long.
MolForge cross-references it against 0 known binders and
111 disease associations.
Target properties
| Protein name | Maleylacetoacetate isomerase |
|---|
| UniProt accession | O43708 |
|---|
| Gene | GSTZ1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 216 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (111)
Diseases linked to this target (Open Targets).
- maleylacetoacetate isomerase deficiency · score 0.61
- protein measurement · score 0.16
- erythrocyte count · score 0.13
- hepatocellular carcinoma · score 0.12
- eosinophil count · score 0.07
- neoplasm · score 0.07
- leukocyte count · score 0.05
- Congenital bile acid synthesis defect type 1 · score 0.04
- cirrhosis of liver · score 0.04
- hepatorenocardiac degenerative fibrosis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43708-F1 | alphafold | PREDICTED | 97.27 | — |
Amino-acid sequence (216 residues)
MQAGKPILYS YFRSSCSWRV RIALALKGID YKTVPINLIK DRGQQFSKDF QALNPMKQVP TLKIDGITIH QSLAIIEYLE EMRPTPRLLP QDPKKRASVR MISDLIAGGI QPLQNLSVLK QVGEEMQLTW AQNAITCGFN ALEQILQSTA GIYCVGDEVT MADLCLVPQV ANAERFKVDL TPYPTISSIN KRLLVLEAFQ VSHPCRQPDT PTELRA
Explore Maleylacetoacetate isomerase with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets