18S rRNA (guanine-N(7))-methyltransferase (BUD23)

About 18S rRNA (guanine-N(7))-methyltransferase

18S rRNA (guanine-N(7))-methyltransferase (BUD23) is a protein from Homo sapiens identified by UniProt accession O43709, 281 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	18S rRNA (guanine-N(7))-methyltransferase
UniProt accession	O43709
Gene	BUD23
Organism	Homo sapiens
Length	281 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

IGF-1 measurement · score 0.18
appendicular lean mass · score 0.09
MODY · score 0.07
3-hydroxy-3-methylglutaryl-CoA synthase deficiency · score 0.05
hyperproinsulinemia · score 0.05
exercise-induced hyperinsulinism · score 0.04
Glycogen storage disease due to hepatic glycogen synthase deficiency · score 0.04
glycogen storage disorder due to hepatic glycogen synthase deficiency · score 0.04
lean body mass · score 0.04
alcohol consumption measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43709-F1	alphafold	PREDICTED	87.73	—

Amino-acid sequence (281 residues)

MASRGRRPEH GGPPELFYDE TEARKYVRNS RMIDIQTRMA GRALELLYLP ENKPCYLLDI GCGTGLSGSY LSDEGHYWVG LDISPAMLDE AVDREIEGDL LLGDMGQGIP FKPGTFDGCI SISAVQWLCN ANKKSENPAK RLYCFFASLF SVLVRGSRAV LQLYPENSEQ LELITTQATK AGFSGGMVVD YPNSAKAKKF YLCLFSGPST FIPEGLSENQ DEVEPRESVF TNERFPLRMS RRGMVRKSRA WVLEKKERHR RQGREVRPDT QYTGRKRKPR F

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards