TP53-regulated inhibitor of apoptosis 1 (TRIAP1)

About TP53-regulated inhibitor of apoptosis 1

TP53-regulated inhibitor of apoptosis 1 (TRIAP1) is a protein from Homo sapiens identified by UniProt accession O43715, 76 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.

Target properties

Protein name	TP53-regulated inhibitor of apoptosis 1
UniProt accession	O43715
Gene	TRIAP1
Organism	Homo sapiens
Length	76 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (57)

Diseases linked to this target (Open Targets).

reticulocyte count · score 0.15
alkaline phosphatase measurement · score 0.14
reticulocyte measurement · score 0.11
serum gamma-glutamyl transferase measurement · score 0.11
lifestyle measurement · score 0.10
balding measurement · score 0.10
body fat percentage · score 0.09
lean body mass · score 0.08
sex hormone-binding globulin measurement · score 0.08
fat body mass · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43715-F1	alphafold	PREDICTED	87.64	—

Amino-acid sequence (76 residues)

MNSVGEACTD MKREYDQCFN RWFAEKFLKG DSSGDPCTDL FKRYQQCVQK AIKEKEIPIE GLEFMGHGKE KPENSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards