About Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (GATC) is a protein
from Homo sapiens identified by UniProt accession
O43716, 136 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial |
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| UniProt accession | O43716 |
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| Gene | GATC |
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| Organism | Homo sapiens |
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| Length | 136 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (37)
Diseases linked to this target (Open Targets).
- combined oxidative phosphorylation deficiency 42 · score 0.48
- reticulocyte count · score 0.33
- alkaline phosphatase measurement · score 0.30
- mean corpuscular volume · score 0.25
- reticulocyte measurement · score 0.25
- sex hormone-binding globulin measurement · score 0.24
- red blood cell density measurement · score 0.22
- mean reticulocyte volume · score 0.20
- osteoarthritis, knee · score 0.13
- Immature Reticulocyte Fraction Measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43716-F1 | alphafold | PREDICTED | 78.56 | — |
Amino-acid sequence (136 residues)
MWSRLVWLGL RAPLGGRQGF TSKADPQGSG RITAAVIEHL ERLALVDFGS REAVARLEKA IAFADRLRAV DTDGVEPMES VLEDRCLYLR SDNVVEGNCA DELLQNSHRV VEEYFVAPPG NISLPKLDEQ EPFPHS
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