About 17S U2 SnRNP complex component HTATSF1
17S U2 SnRNP complex component HTATSF1 (HTATSF1) is a protein
from Homo sapiens identified by UniProt accession
O43719, 755 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | 17S U2 SnRNP complex component HTATSF1 |
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| UniProt accession | O43719 |
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| Gene | HTATSF1 |
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| Organism | Homo sapiens |
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| Length | 755 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (16)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- environmental tobacco smoke exposure measurement · score 0.13
- neoplasm · score 0.08
- cancer · score 0.03
- Neoplasm of the lung · score 0.02
- chronic kidney disease · score 0.01
- pituitary cancer · score 0.01
- Vitiligo · score 0.01
- Alzheimer disease · score 0.00
- carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43719-F1 | alphafold | PREDICTED | 59.11 | — |
Amino-acid sequence (755 residues)
MSGTNLDGND EFDEQLRMQE LYGDGKDGDT QTDAGGEPDS LGQQPTDTPY EWDLDKKAWF PKITEDFIAT YQANYGFSND GASSSTANVE DVHARTAEEP PQEKAPEPTD ARKKGEKRKA ESGWFHVEED RNTNVYVSGL PPDITVDEFI QLMSKFGIIM RDPQTEEFKV KLYKDNQGNL KGDGLCCYLK RESVELALKL LDEDEIRGYK LHVEVAKFQL KGEYDASKKK KKCKDYKKKL SMQQKQLDWR PERRAGPSRM RHERVVIIKN MFHPMDFEDD PLVLNEIRED LRVECSKFGQ IRKLLLFDRH PDGVASVSFR DPEEADYCIQ TLDGRWFGGR QITAQAWDGT TDYQVEETSR EREERLRGWE AFLNAPEANR GLRRSDSVSA SERAGPSRAR HFSEHPSTSK MNAQETATGM AFEEPIDEKK FEKTEDGGEF EEGASENNAK ESSPEKEAEE GCPEKESEEG CPKRGFEGSC SQKESEEGNP VRGSEEDSPK KESKKKTLKN DCEENGLAKE SEDDLNKESE EEVGPTKESE EDDSEKESDE DCSEKQSEDG SEREFEENGL EKDLDEEGSE KELHENVLDK ELEENDSENS EFEDDGSEKV LDEEGSEREF DEDSDEKEEE EDTYEKVFDD ESDEKEDEEY ADEKGLEAAD KKAEEGDADE KLFEESDDKE DEDADGKEVE DADEKLFEDD DSNEKLFDEE EDSSEKLFDD SDERGTLGGF GSVEEGPLST GSSFILSSDD DDDDI
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