About ER lumen protein-retaining receptor 3
ER lumen protein-retaining receptor 3 (KDELR3) is a protein
from Homo sapiens identified by UniProt accession
O43731, 214 residues long.
MolForge cross-references it against 0 known binders and
82 disease associations.
Target properties
| Protein name | ER lumen protein-retaining receptor 3 |
|---|
| UniProt accession | O43731 |
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| Gene | KDELR3 |
|---|
| Organism | Homo sapiens |
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| Length | 214 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (82)
Diseases linked to this target (Open Targets).
- prostate carcinoma · score 0.36
- sex hormone-binding globulin measurement · score 0.19
- mean corpuscular hemoglobin concentration · score 0.18
- cholelithiasis · score 0.17
- age at menopause · score 0.16
- triglyceride measurement · score 0.15
- hematocrit · score 0.13
- BMI-adjusted hip circumference · score 0.12
- mean corpuscular volume · score 0.11
- breast adenocarcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43731-F1 | alphafold | PREDICTED | 91.35 | — |
Amino-acid sequence (214 residues)
MNVFRILGDL SHLLAMILLL GKIWRSKCCK GISGKSQILF ALVFTTRYLD LFTNFISIYN TVMKVVFLLC AYVTVYMIYG KFRKTFDSEN DTFRLEFLLV PVIGLSFLEN YSFTLLEILW TFSIYLESVA ILPQLFMISK TGEAETITTH YLFFLGLYRA LYLANWIRRY QTENFYDQIA VVSGVVQTIF YCDFFYLYVT KVLKGKKLSL PMPI
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