About E3 ubiquitin ligase TRAF3IP2
E3 ubiquitin ligase TRAF3IP2 (TRAF3IP2) is a protein
from Homo sapiens identified by UniProt accession
O43734, 574 residues long.
MolForge cross-references it against 0 known binders and
372 disease associations.
Target properties
| Protein name | E3 ubiquitin ligase TRAF3IP2 |
|---|
| UniProt accession | O43734 |
|---|
| Gene | TRAF3IP2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 574 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (372)
Diseases linked to this target (Open Targets).
- Chronic mucocutaneous candidosis · score 0.68
- rheumatoid arthritis · score 0.57
- psoriasis · score 0.51
- neurodegenerative disease · score 0.41
- Sjogren syndrome · score 0.40
- chronic mucocutaneous candidiasis · score 0.37
- psoriatic arthritis · score 0.37
- psoriasis vulgaris · score 0.35
- discoid lupus erythematosus · score 0.34
- C-reactive protein measurement · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43734-F1 | alphafold | PREDICTED | 53.21 | — |
Amino-acid sequence (574 residues)
MPPQLQETRM NRSIPVEVDE SEPYPSQLLK PIPEYSPEEE SEPPAPNIRN MAPNSLSAPT MLHNSSGDFS QAHSTLKLAN HQRPVSRQVT CLRTQVLEDS EDSFCRRHPG LGKAFPSGCS AVSEPASESV VGALPAEHQF SFMEKRNQWL VSQLSAASPD TGHDSDKSDQ SLPNASADSL GGSQEMVQRP QPHRNRAGLD LPTIDTGYDS QPQDVLGIRQ LERPLPLTSV CYPQDLPRPL RSREFPQFEP QRYPACAQML PPNLSPHAPW NYHYHCPGSP DHQVPYGHDY PRAAYQQVIQ PALPGQPLPG ASVRGLHPVQ KVILNYPSPW DHEERPAQRD CSFPGLPRHQ DQPHHQPPNR AGAPGESLEC PAELRPQVPQ PPSPAAVPRP PSNPPARGTL KTSNLPEELR KVFITYSMDT AMEVVKFVNF LLVNGFQTAI DIFEDRIRGI DIIKWMERYL RDKTVMIIVA ISPKYKQDVE GAESQLDEDE HGLHTKYIHR MMQIEFIKQG SMNFRFIPVL FPNAKKEHVP TWLQNTHVYS WPKNKKNILL RLLREEEYVA PPRGPLPTLQ VVPL
Explore E3 ubiquitin ligase TRAF3IP2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets