Cytohesin-3 (CYTH3)

About Cytohesin-3

Cytohesin-3 (CYTH3) is a protein from Homo sapiens identified by UniProt accession O43739, 400 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.

Target properties

Protein name	Cytohesin-3
UniProt accession	O43739
Gene	CYTH3
Organism	Homo sapiens
Length	400 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (62)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.35
protein measurement · score 0.27
platelet count · score 0.13
insulin resistance · score 0.07
neonatal intrahepatic cholestasis due to citrin deficiency · score 0.05
Pallister-Hall syndrome · score 0.04
LIPE-related familial partial lipodystrophy · score 0.04
glycogen storage disease VI · score 0.04
high density lipoprotein cholesterol measurement · score 0.04
familial partial lipodystrophy, Kobberling type · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43739-F1	alphafold	PREDICTED	84.20	—

Amino-acid sequence (400 residues)

MDEDGGGEGG GVPEDLSLEE REELLDIRRR KKELIDDIER LKYEIAEVMT EIDNLTSVEE SKTTQRNKQI AMGRKKFNMD PKKGIQFLIE NDLLQSSPED VAQFLYKGEG LNKTVIGDYL GERDEFNIKV LQAFVELHEF ADLNLVQALR QFLWSFRLPG EAQKIDRMME AFASRYCLCN PGVFQSTDTC YVLSFAIIML NTSLHNHNVR DKPTAERFIA MNRGINEGGD LPEELLRNLY ESIKNEPFKI PEDDGNDLTH TFFNPDREGW LLKLGGGRVK TWKRRWFILT DNCLYYFEYT TDKEPRGIIP LENLSIREVE DPRKPNCFEL YNPSHKGQVI KACKTEADGR VVEGNHVVYR ISAPSPEEKE EWMKSIKASI SRDPFYDMLA TRKRRIANKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards