About Small glutamine-rich tetratricopeptide repeat-containing protein alpha
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) is a protein
from Homo sapiens identified by UniProt accession
O43765, 313 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | Small glutamine-rich tetratricopeptide repeat-containing protein alpha |
|---|
| UniProt accession | O43765 |
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| Gene | SGTA |
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| Organism | Homo sapiens |
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| Length | 313 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (69)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.29
- bone density · score 0.25
- urate measurement · score 0.25
- total cholesterol measurement · score 0.12
- platelet count · score 0.09
- sex hormone-binding globulin measurement · score 0.08
- testosterone measurement · score 0.08
- 46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency · score 0.06
- low density lipoprotein cholesterol measurement · score 0.06
- infection · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43765-F1 | alphafold | PREDICTED | 81.06 | — |
Amino-acid sequence (313 residues)
MDNKKRLAYA IIQFLHDQLR HGGLSSDAQE SLEVAIQCLE TAFGVTVEDS DLALPQTLPE IFEAAATGKE MPQDLRSPAR TPPSEEDSAE AERLKTEGNE QMKVENFEAA VHFYGKAIEL NPANAVYFCN RAAAYSKLGN YAGAVQDCER AICIDPAYSK AYGRMGLALS SLNKHVEAVA YYKKALELDP DNETYKSNLK IAELKLREAP SPTGGVGSFD IAGLLNNPGF MSMASNLMNN PQIQQLMSGM ISGGNNPLGT PGTSPSQNDL ASLIQAGQQF AQQMQQQNPE LIEQLRSQIR SRTPSASNDD QQE
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