About Asparagine--tRNA ligase, cytoplasmic
Asparagine--tRNA ligase, cytoplasmic (NARS1) is a protein
from Homo sapiens identified by UniProt accession
O43776, 548 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | Asparagine--tRNA ligase, cytoplasmic |
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| UniProt accession | O43776 |
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| Gene | NARS1 |
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| Organism | Homo sapiens |
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| Length | 548 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (63)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with microcephaly, impaired language, and gait abnormalities · score 0.73
- Neurodevelopmental disorder · score 0.57
- neurodevelopmental disorder with microcephaly, impaired language, epilepsy, and gait abnormalities · score 0.56
- mitochondrial complex I deficiency · score 0.33
- mitochondrial complex 1 deficiency, nuclear type 35 · score 0.33
- mean corpuscular volume · score 0.24
- hemoglobin measurement · score 0.23
- mean corpuscular hemoglobin · score 0.22
- serum gamma-glutamyl transferase measurement · score 0.21
- mean corpuscular hemoglobin concentration · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43776-F1 | alphafold | PREDICTED | 93.85 | — |
Amino-acid sequence (548 residues)
MVLAELYVSD REGSDATGDG TKEKPFKTGL KALMTVGKEP FPTIYVDSQK ENERWNVISK SQLKNIKKMW HREQMKSESR EKKEAEDSLR REKNLEEAKK ITIKNDPSLP EPKCVKIGAL EGYRGQRVKV FGWVHRLRRQ GKNLMFLVLR DGTGYLQCVL ADELCQCYNG VLLSTESSVA VYGMLNLTPK GKQAPGGHEL SCDFWELIGL APAGGADNLI NEESDVDVQL NNRHMMIRGE NMSKILKARS MVTRCFRDHF FDRGYYEVTP PTLVQTQVEG GATLFKLDYF GEEAFLTQSS QLYLETCLPA LGDVFCIAQS YRAEQSRTRR HLAEYTHVEA ECPFLTFDDL LNRLEDLVCD VVDRILKSPA GSIVHELNPN FQPPKRPFKR MNYSDAIVWL KEHDVKKEDG TFYEFGEDIP EAPERLMTDT INEPILLCRF PVEIKSFYMQ RCPEDSRLTE SVDVLMPNVG EIVGGSMRIF DSEEILAGYK REGIDPTPYY WYTDQRKYGT CPHGGYGLGL ERFLTWILNR YHIRDVCLYP RFVQRCTP
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