About Dual specificity tyrosine-phosphorylation-regulated kinase 3
Dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3) is a protein
from Homo sapiens identified by UniProt accession
O43781, 588 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Dual specificity tyrosine-phosphorylation-regulated kinase 3 |
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| UniProt accession | O43781 |
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| Gene | DYRK3 |
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| Organism | Homo sapiens |
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| Length | 588 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (52)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.36
- mean corpuscular hemoglobin concentration · score 0.32
- mean corpuscular hemoglobin · score 0.30
- neurodegenerative disease · score 0.27
- Alzheimer disease · score 0.23
- Parkinson disease · score 0.23
- lysosomal storage disease · score 0.23
- multiple sclerosis · score 0.23
- left atrial volume measurement · score 0.15
- melanoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43781-F1 | alphafold | PREDICTED | 75.00 | — |
Amino-acid sequence (588 residues)
MGGTARGPGR KDAGPPGAGL PPQQRRLGDG VYDTFMMIDE TKCPPCSNVL CNPSEPPPPR RLNMTTEQFT GDHTQHFLDG GEMKVEQLFQ EFGNRKSNTI QSDGISDSEK CSPTVSQGKS SDCLNTVKSN SSSKAPKVVP LTPEQALKQY KHHLTAYEKL EIINYPEIYF VGPNAKKRHG VIGGPNNGGY DDADGAYIHV PRDHLAYRYE VLKIIGKGSF GQVARVYDHK LRQYVALKMV RNEKRFHRQA AEEIRILEHL KKQDKTGSMN VIHMLESFTF RNHVCMAFEL LSIDLYELIK KNKFQGFSVQ LVRKFAQSIL QSLDALHKNK IIHCDLKPEN ILLKHHGRSS TKVIDFGSSC FEYQKLYTYI QSRFYRAPEI ILGSRYSTPI DIWSFGCILA ELLTGQPLFP GEDEGDQLAC MMELLGMPPP KLLEQSKRAK YFINSKGIPR YCSVTTQADG RVVLVGGRSR RGKKRGPPGS KDWGTALKGC DDYLFIEFLK RCLHWDPSAR LTPAQALRHP WISKSVPRPL TTIDKVSGKR VVNPASAFQG LGSKLPPVVG IANKLKANLM SETNGSIPLC SVLPKLIS
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